INDICATIONS:
Conditions where the anti-inflammatory and immunosuppressive effects of the corticosteroids are desirable, especially for intensive treatment during shorter periods.
In addition, for the management of nausea and vomiting associated with cisplatin and non-cisplatin emetogenic chemotherapy.

USE IN PREGNANCY AND MOTHERS:
Since human reproduction studies have not been done with coticosteroids the use of these drugs in pregnancy, or in women of childbearing potential requires that the anticipated benefits be weighed against the possible hazards to the mother and embryo or fetus infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be caredully observed for signs of hypoadrenalism corticosteroids appear in breast milk and suppress growth, interfere with endogenous corticosteroid production, or cause other unwanted effects in the breast feeding infants. Mother taking pharmacologic doses of corticosteroids sould be advised not to nurse.

DOSAGE AND ADMINISTRATION:
INTRAVENOUS AND INTRAMUSCLAR INJECTION:
The usual initial dosage of DEXAMEDRON injcection may vary from 0.5 mg to 20 mg per day depending on the specific disease entity being treated. Usually the parenteral dose is one-third to one-half of the oral dose, given every 12 hours. However, in certain overwhelming, acute, lifethreatening situations, dosages exceeding the usual recommended dosages have been used. In these circumstances, the slower rate of absorption by intramuscular administration should be recognized.DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATEMENT AND THE RESPONSE OF THE PATIENT.If the drug is to be stopped after it has been given for more than a few days, it is recommended that it be withdrawn gradually rather than stopped abruptly. In emergencies, the usual dose is 1ml to 5ml (4mg to 20mg) I.V. or I.M (in shock use only the I.V. route). This dose may be repeated until adequate response in noted.
INTRA-ARTICULAR, INTRALESIONAL AND SOFT-TISSUE INJECTION:
Intra-articular, intralesional, and soft-tissue injection  generally are employed when affected joints or areas are limited to one or two sites.
The frequency of injection varies from once every 3 to 6 das to once every 2 to 3 weeks, depending on the response to treatment.

STORAGE:
Store ina a cool, dry place. Keep out of the reach of children.

PACKING:
Dexamedron is available in 1 ml (25 x 1 ml pack).

Manufactured by:
Goefman Pharmaceuticals,Pakistan.