Degut (Domperidone), a dopamine antagonist acts by selectively blocking D 2 dopamine receptor. Since it can’t readily enter the central nervous system due to blood brain barrier, its effects are confined to the periphery and acts principally at the receptors in the chemoreceptor trigger zone.
INDICATION
It is used as an antiemetic for the short term treatment of nausea and vomiting of various aetiologies, including that associated with levodopa or bromocriptine therapy for parkinsonism. Also used for its prokinetic actions in dyspepsia.
DOSAGE AND ASMINISTRATION
Degut should be taken 15-30 minutes before meal.
In case of acute nausea and vomiting the recommended oral dose for-
Adult: 10-20 mg (1-2 tablets) or 10 to 20 ml suspension every 4-8 hours.
Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg) body  weight every 4-8 hours.
In case of functional dyspepsia-
Adult: 10-20 mg (1-2 tablets ) or 10 to 20 ml suspension 3 times daily before meal and at night.
Children: Not recommended.
For acute nausea, vomiting and functional dyspepsia, maximum period of treatment is 12 weeks.
USE  IN PREGNANCY  AND  LACTATION
The safety of domperidone has not been proven and it is therefore  not recommended during pregnancy. Animal studies have not demonstrated teratogenic effects on the fetus.
Domperidone may precipitate galactorrhoea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.
PACKAGING
Degut tablet: Each box containing 10x 10 tablets in Alu/PVC blister pack.
STORAGE CONDITION
Store below 30 c.
Protect from light & moisture.
PRECAUTION
Keep out of the reach of children.

Manufacturer's
Delta Pharma Co.,Ltd, Bangladesh