Description: 

Ambroxol is a metabolite of Bromhexine. It has been proven that it possesses mucokinetic 

(improvement in mucus transport) and secretolytic (liquefies secretion) properties. Ambroxol stimulates the serous cells of the glands of the mucus membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. It stimulates production of phospholipids of surfactant by alveolar cells. Ambroxol has anti-inflammatory porperties. In patient with COPD, it imporves airway patency. Ambroxol alsoexhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation. 

Indications 

• Acute and chronic disease of respiratory tracts associated with viscid mucous including acute & chronic bronchitis. 
• Productive cough 
• Inflammatory diseases of Rhinopharyngeal tract 
• Asthmatic bronchitis, Bronchial asthma with thick expectoration --Bronchiectasis 
• Chronic pneumonia 

Dosage &Administration: 

Average daily dose (preferably after meal) :12 years old and adults 1 Capsule, once daily 

Side-effects: 

Gastrointestinal side effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic response such as eruption, urticaria or angioneurotic edema may occur. 

Precautions: 

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive 

disorders. Patients with hepatic and renal insufficiency should take it with caution. 

Use In Pregnancy and Lactation: 

Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. 

However, it is advised not to use during pregnancy, especially in the 1st trimester. 

Lactation: Safety during Lactation has not yet been established. 

Contraindication: 

Contraindicated in known hypersensitivity to Ambroxol or Bromhexine. 

Drug Interactions: 

Ambroxol has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary infection). But Ambroxol should not be taken simultaneously with antitussive (e.g. Codeine) because mucus, which has been liquefied by Ambroxol, might not be expectorated. 

Presentation: 

Lytex SR Capsule: Each Box contains 6 x 5's capsules in blister pack.

Manufactured by:
The IBN SINA Pharmaceutical Industry Ltd,Bangladesh.